A comparison between the efficacy of methylphenidate and cocaine for nasal vasoconstriction before nasal surgery—A randomized prospective study

Objectives: Cocaine is regularly utilized topically to give the vasoconstriction to nasal medical procedure; However, it is said to create intraoperative cardiovascular unfriendly impacts. Methylphenidate was considered in the place of cocaine as a substitute to look at the vasoconstriction in nasal medical procedure. Methods: Outcome of the study will be examining the vasoconstriction based on a 5-point scale (1 = unacceptable, 5 = excellent), followed by the administration of either 20–30 mg per day methylphenidate or 4% cocaine randomly to the adult patients subjected to nasal septoplasty. Results: Methylphenidate and cocaine were administered with 38 and 28 patients respectively. The quality of vasoconstriction was noticed to be good in both the groups with the median rating of 4.0 and a P value of 0.85. With both the gatherings, the median blood loss was 46 and 58 ml with a p estimation of 0.48. A non-mediocrity delta of 1 point with a p estimation of 0.009 and non-inadequacy delta of 24 ml with a p esteem 0.026 concerning vasoconstriction and blood loss individually is seen which demonstrates methylphenidate is comparable to cocaine. Non importance is noted with the recurrence of ventricular ectopy, ST section changes after nasal packing with the gatherings. Conclusions: With the results obtained, methylphenidate can be very well replaced for cocaine for vasoconstriction in septoplasty. As there are lot many underlying chances for cocaine abuse and administrative issues related to its handling, methylphenidate may serve as a substitute

A Study on Occupational Stress among Arts and Science College Faculties in Kanyakumari District, Tamil Nadu

Purpose:The goal of this research is to explore the occupational stress level of faculties working in Arts and Science College in Kanyakumari District, Tamil Nadu, India. Teachers of any country are respectable and they are valuables to their country. Tomorrow’s nation is in the hands of the teachers who sculpt the students. Among all the profession in the world, there is a significant place for teaching profession. Recent days, teacher’s job is also like a managerial job as they play a multi-dimensional work commitment. In that case, the stress of the teacher’s can’t be avoided, but it can be nullified when they know how to control it.   Theoretical framework:The theoretical framework highlights the directions in carrying out the research. It shows the factors of occupational stress are independent variables and the facilities of Arts and Science colleges are dependent variables. The relationships between the variables are studied in this research.   Design/Methodology/Approach:The primary sources of the data are collected through personal interview and structured questionnaire and the statistical analysis is carried out through Percentage analysis, T-test and correlation.   Findings:From the study it is found that occupational stress of female faculties is high when compared with male teachers. The study shows the significant difference was observed among male and female faculties on occupational stress. The factors that cause occupational stress is also discussed in the study. A significant and positive correction is observed among the varieties of occupational stress.   Research, practical &  social  implications: The college management should look for some aid from psychologists to direct faculties freeing from their frustration and anger. College management can provide training and workshops which helps to enhance the skills of faculties and develop a rapport among co-workers.    Originality/value:The variables of the studies are analysed and it shows the meaningful effect on the occupational stress of faculties. Then the research is concluded with the certainty that occupational stress of the facilities is nullified and the performance will be increased

Green Entrepreneurs Challenges and Innovation: The Struggles They Face

Purpose:  A green entrepreneur's enterprise prioritises environmental protection by minimising the negative impact of existing products, services, or processes. It contributes to the beneficial transformation of society. This study discusses green entrepreneur challenges and innovations in Tamil Nadu's Salem District.  The intention of this study is to determine what factors determine the obstacles they experience in their business and how to transform those obstacles into opportunities   Design/methodology/approach:  Snowball sampling is employed to choose the population for this study from Salem's vast population, and the total number of respondents chosen is 50.   Findings: Simple Percentage Analysis, Chi-Square, and the Henry Garrett Ranking Method are utilised for measuring the factors. The result of testing the hypothesis indicates that there is no correlation between age and the influence to start a business using technical or professional knowledge and skill   Future Implications: Our work presents a range of theoretical and practical implications, as previously said, but it is not without limitations. In order to ascertain the direct and indirect effects of stakeholder demands, green dynamic capacity, green innovation, and firm performance, we first propose that future research make use of our framework and conduct a comparison study of small and large enterprise

Design of an Intelligent Controller for Armature Controlled DC Motor using Fuzzy Logic Technique

This paper presents a fuzzy control approach to the speed control of DC shunt motor using armature control. This paper presents concept of development of conventional controller and the design of a fuzzy logic controller applicable to DC Motor Speed Control System (MSCS) with high performance of the FL controller. Since armature voltage supply has a major influence in controlling speed, therefore one of the inputs to the proposed FL Controller will be actual armature voltage supply (Va) while another input will be error (e) in speed. The transfer function model of the DC shunt motor has been obtained via experimentation and calculations and simulated and then as per requirement and specification, the proposed fuzzy logic controller has been designed and simulated using Fuzzy Logic and Simulink Toolboxes of MATLAB 7. Results show robustness against changing loading conditions

Enhancement of TbIII-CuII single-molecule magnet performance through structural modification

We report a series of 3d–4f complexes {Ln2Cu3(H3L)2Xn} (X=OAc−, Ln=Gd, Tb or X=NO3−, Ln=Gd, Tb, Dy, Ho, Er) using the 2,2′-(propane-1,3-diyldiimino)bis[2-(hydroxylmethyl)propane-1,3-diol] (H6L) pro-ligand. All complexes, except that in which Ln=Gd, show slow magnetic relaxation in zero applied dc field. A remarkable improvement of the energy barrier to reorientation of the magnetisation in the {Tb2Cu3(H3L)2Xn} complexes is seen by changing the auxiliary ligands (X=OAc− for NO3−). This leads to the largest reported relaxation barrier in zero applied dc field for a Tb/Cu-based single-molecule magnet. Ab initio CASSCF calculations performed on mononuclear TbIII models are employed to understand the increase in energy barrier and the calculations suggest that the difference stems from a change in the TbIII coordination environment (C4v versus Cs)

Studies on Correlation and Path Analysis in Mutants of Coleus (Coleus forskohlii Briq.) for Yield and forskolin Content in V2M1 Generation

The present investigation was carried out during 2003-2007 involving terminal cuttings of coleus ecotype 'Garmai'. Genotypic correlation coefficient between yield and its components in mutants of coleus was studied, viz., plant height, number of branches plant-1, number of leaves plant-1, number of tubers plant-1, tuber length and tuber girth were found to have positive and highly significant correlation with yield. However, forskolin and essential oil content showed negative correlation with yield. Path analysis of component characters on yield of Coleus in V2M1 generation exerted positive direct effect through the characters plant height, number of leaves plant-1 and number of tubers plant-1. Similarly, direct effect was observed to be negative through number of branches plant-1 (-0.930), total amount of alkaloids (-0.066) and forskolin content (-0.026). The current investigation resulted in residual effect of 0.158 indicating the accuracy and appropriate selection of component character for crop improvement programme. Weightage must be given to component characters exhibiting positive attributes towards fresh tuber yield in Coleus. However, some traits with negative attributes are also chosen for getting improved quality, i.e., forskolin content, without much inhibition on fresh tuber yield plant-1

The 2 micron plasmid purloins the yeast cohesin complex: a mechanism for coupling plasmid partitioning and chromosome segregation?

The yeast 2 micron plasmid achieves high fidelity segregation by coupling its partitioning pathway to that of the chromosomes. Mutations affecting distinct steps of chromosome segregation cause the plasmid to missegregate in tandem with the chromosomes. In the absence of the plasmid stability system, consisting of the Rep1 and Rep2 proteins and the STB DNA, plasmid and chromosome segregations are uncoupled. The Rep proteins, acting in concert, recruit the yeast cohesin complex to the STB locus. The periodicity of cohesin association and dissociation is nearly identical for the plasmid and the chromosomes. The timely disassembly of cohesin is a prerequisite for plasmid segregation. Cohesin-mediated pairing and unpairing likely provides a counting mechanism for evenly partitioning plasmids either in association with or independently of the chromosomes

Screening and characterization of antimicrobial secondary metabolites from Halomonas salifodinae MPM-TC and its in vivo antiviral influence on Indian white shrimp Fenneropenaeus indicus against WSSV challenge

AbstractAntimicrobial secondary metabolites from extremophiles play a significant role in the pharmacological industry due to their stable and strong activity and it is used in the treatment of microbial infections. In the present work, Halomonas salifodinae MPM-TC (M. Peter Marian-T. Citarasu) was isolated from the solar salt works in India and identified by 16S rRNA sequencing. The secondary metabolites were extracted from H. salifodinae MPM-TC and tested for antibacterial activity against aquatic bacterial pathogens such as Vibrio harveyi, Vibrio parahaemolyticus, Pseudomonas aeruginosa and Aeromonas hydrophila isolated from infected fish/shrimp, and it effectively controlled them with more than 10mm of zone of inhibition. The metabolites were purified through silica column chromatography and in vitro antiviral activity was performed against White Spot Syndrome Virus (WSSV) using different fractions. Among the different tested fractions, fraction-III (F-III) was able to suppress WSSV replication. Shrimps challenged with a WSSV inoculum incubated with F-III and treated Fenneropenaeus indicus survived around twice as many as the controls. Gas chromatography–mass spectroscopic (GC–MS) analysis revealed that the antiviral active fraction contains around eight compounds including Perfluorotributylamine, Cyclopentane, 1-butyl-2-ethyl and 1,1′-Biphenyl]-3-amine. Further the active fraction F-III was incorporated in the artificial diets at the concentration of 200 (HS1), 400 (HS2) and 800 (HS3) μgkg−1 and fed to F. indicus for 30days. After 30days of culture, shrimps were challenged with virulent WSSV and studied for WSSV VP 28 gene expression, biochemical, haematological and immunological changes. Surprisingly, groups treated with lower concentrations of fraction F-III (HS1 or HS2) significantly (P<0.05) suppressed the viral replication. Different levels of protein and glucose, improved total haemocyte count (THC), coagulase activity and oxyhaemocyanin level all were comparable to controls. Also, immunological parameters such as prophenol oxidase and intracellular superoxide anion production were significantly increased (F=97.18; P⩽0.001 and F=5.70; P⩽0.05) in the groups treated with the three test concentrations. The presence of antiviral and immunostimulant active principles in the F-III fraction effectively suppressed the WSSV load and boosted F. indicus’s immune system. This research will help to develop novel antiviral drugs from plants against aquatic important pathogens

4-Chloro-2,5-dimethyl­quinoline

Mol­ecules of the title compound, C11H10ClN, are essentially planar (r.m.s. deviation for all non-H atoms = 0.009 Å) and are stacked along the a axis with the centroids of the benzene and pyridine rings alternately separated by 3.649 (1) and 3.778 (1) Å